Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration
نویسندگان
چکیده
منابع مشابه
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal m...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.12.083